Platform
The Rev-Mod Platform
Our proprietary Rev-Mod Platform uses a modular plug-and-play system to streamline and accelerate the efficient drug discovery and development of multispecific biologics across a broad range of diseases.
The Multi-Mod
This customizable multispecific biologic is built from highly compatible modular subunits to provide innovative solutions to complex diseases.1
The True Human
Multi-Mod
It's also enabled by a naturally occurring, fully human, universal light chain that supports the integration of diverse binding domains.1
The Rev-Mod Platform can be used to rapidly and
effectively create multispecific biologics.
Bi-Mod Biologics
Can be used to target 2 distinct
disease pathways.
Tri-Mod Biologics
Can be used to target 3 distinct disease pathways. Our first-in-class candidate,
RO-104, is a Tri-Mod biologic designed to treat retinal vascular disease.
Tetra-Mod Biologics and Beyond
Can be used to singularly target 4+ distinct disease pathways.
Rev-Mod
Benefits of the Rev-Mod Platform1
One molecule, multiple targets:
- Native, non-engineered biologics
- Elegant modular solutions
- Targets multiple disease pathways
Fully human:
- Fully human antibody sequences and architecture
- Maximizing efficacy and drug-like properties
- Well tolerated by the human body
Derived from nature:
- Light chain based on the surrogate light chain
- Naturally occurring precursor formed in all humans
- Universal natural partner for all human heavy chain binding domains
Rapid discovery and development:
- Platform supports efficient screening
- Customizable plug-and-play design of molecules
- Optimal solutions to complex diseases
Reference: 1. Xu L, et al. Proc Natl Acad Sci USA. 2008;105(31):10756-10761.